ACP can be injected intradermally. The regeneration process is initiated by the release of growth factors following the endogenic activation of platelets. ACP stimulates the breakdown of sun-damaged elements of the extracellular matrix and induces the synthesis of collagen. A significant improvement in skin elasticity has been reported in a number of studies as a direct result. It has also proved possible to demonstrate a considerably higher quantity and size of collagen bundles. The synthesis of hyaluronic acid stimulated by ACP has additionally been shown to produce a volume effect and enhance skin turgor. ACP is also ideal for combination with medical needling. Numerous studies have demonstrated how the combination of PRP and microneedling leads to better clinical results and higher patient satisfaction compared with microneedling (plus vitamin C) alone. Overall, treatment with ACP results in improved skin texture and increased glow for the patient as well as volume improvements to a certain degree. In addition to the skin of the face, the literature also describes successful treatment results around the eyes, on the hands, on the neck and décolleté, and for striae distensae (stretch marks).
ACP as a Supportive Treatment Following (Fractionated) Ablative Laser Treatment
(Fractionated) ablative laser systems are often used for skin rejuvenation in aesthetic medicine. The topical application or injection of ACP following ablative (fractionated) laser treatment offers the possibility of the implementation of a regenerative procedure in a mechanical treatment concept. In studies, ACP following laser treatment demonstrated proliferation-promoting effects, reduced the transepidermal water loss (TEWL), and accelerated the healing overall. In addition, patients found the laser procedure with ACP to be cosmetically better than that without PRP and gave it a better satisfaction rating.
Androgenetic Alopecia and Alopecia Areata
ACP injected into the scalp is a treatment option for hair loss (androgenetic alopecia and alopecia areata). ACP stimulates the proliferation and differentiation of stem cells in hair follicles. The growth factor VEGF (vascular endothelial growth factor) triggers neoangiogenesis and stimulates the blood supply to the hair follicles. In addition, the dormant hair follicles are stimulated by the growth factors released. Clinical studies have shown a significant increase in the diameter and thickness of the hair. In addition, it has been possible to demonstrate better results both clinically and trichoscopically compared with minoxidil, one of the most widely used medications in the treatment of hair loss. Multiple applications are usually required to achieve the desired result. ACP can also be effectively employed to improve the overall clinical result in the case of hair transplants. In this respect, PRP can be used preoperatively, intraoperatively, and postoperatively. Studies have described the use of PRP to improve the density of the hair follicles.
Wrinkles / Contours / Augmentation
ACP is well tolerated and can produce a significant improvement in wrinkles, without injection of a foreign substance, and with virtually no downtime. The procedure is especially beneficial for finer, superficial wrinkles. Studies also describe the successful use of PRP in combination with fat grafts. ACP supports the vascularization and thus the preservation of the fat graft, among other things.